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Dr. Valdes had begun co-transplanting Sertoli cells with islet cells, both derived from piglets, into humans. Valdes has claimed to reverse diabetes in 31 Mexican patients. Although many of his patients stepped forward to defend Dr. Valdes, the Society censured him for skipping pre-clinical tests on primates. Valdes' former professor at Cambridge University (UK), Dr. David White, is now conducting the mandatory pre-clinical research at the Robarts Research Institute at the University of Western Ontario. Dr. White is also chairman of the scientific advisory board of Sernova Corp, which is funding the research to develop a commercial product to reverse Type 1 diabetes. Dr. White said of Valdes' research, "Clinically, his work has extraordinary potential." Previous attempts at xenotransplanting animal islet cells into humans failed because researchers could not get those cells to survive for long in a human body. Dr. White believes Valdes' pioneering work could help him develop a revolutionary new therapy.
We spoke with Dr. White this past June at his offices in London, Ontario. He hoped to 'back track' Dr. Valdes work by starting with rodent studies and moving forward to primate trials. This would appear to satisfy the demands by the Xenotransplantation Society and provide a scientific basis for progressing to human clinical studies. Dr. White told us he hoped his research would improve upon Dr. Valdes' efficacy rate in helping patients become insulin independent. His challenge is to identify the most effective ratio of Sertoli cells to islet cells for the co-transplant process. He envisions diabetes reversal in the coming years without the use of anti-rejection drugs. White told us, "Immunosuppression drugs are very toxic to the human body." He would know. As a young researcher at Cambridge University, Dr. White was part of the research team which helped develop Cyclosporin A, an immune-suppressing drug, to prevent the body from rejecting organ transplants. Perhaps his current research will lead to yet another breakthrough.