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The majority of patients were forced to return to insulin-dependence because one-half to three-quarters of the islet cells died. During the study there were 38 serious adverse events, some of which required hospitalization. Patients are given immune-suppressing drugs after the islet cell transplants to block the immune system from identifying those foreign cells. Complaints from the medical profession criticize the anti-rejection drugs because the immune system fails to work the way nature intended. Patients are at risk of getting infectious diseases and other side effects. Will Sertoli Cells Replace Anti-Rejection Drugs? In unlocking the riddle of keeping the transplanted islet cells alive, the problem may be in the anti-rejection drugs. Camillo Ricordi, M.D., chief cellular transplantation and scientific director of diabetes research at the University of Miami School of Medicine. Numerous researchers are searching for the unique anti-rejection drug which would prevent the body's immune system from destroying the transplanted islets. Seung Kim, M.D., PhD, and assistant professor of developmental biology at the Stanford University School of Medicine recently announced that immune-suppressing drugs inhibit a protein called calcineurin. Dr. Kim discovered when the protein is inhibited, this hampers the beta cells from keeping blood sugar in check.
When the beta cells fail to produce insulin, or too little of it, sugar stagnates in the blood and is not moved into the cells to produce energy for the body. In a nutshell, the anti-rejection drugs, surgeons have used to help islet transplants take hold, might be the culprit which unravels their procedure. Sernova Corp is presently researching Sertoli cells as a replacement for anti-rejection drugs. Sernova President Justin Leushner told StockInterview in a recent telephone interview. Leushner calls Sertoli cells "Mother Nature's anti-rejection drug" because of their immuno-protective property. Several studies involving testicular Sertoli cells with pig islets transplanted into rats and mice have shown promise with this technology. A University of Alberta study, published in Diabetologia (2000, 43:474-480) demonstrated that testicular Sertoli cells can protect allogeneic islet grafts from rejection after transplantation into animals with chemically induced diabetes. In a recent controversy, the prominent Mexican transplant surgeon Dr. Raphael Valdes was given an unusual vote of no confidence by the International Xenotransplantation Society for his reversal of Type 1 diabetes in humans.